Following the description of Japanese herbal medicine, cannabinoids are explained below.

Crude Drugs name: Cannabinoids
Basal plant:
Family; Cannabaceae, Cannabis L.
Binomial name; Cannabis sativa L.
Generic name; Cannabis, Medical marijuana

Parts used:
Inflorescence, Leaves
In Japan, the Cannabis Control Act enacted in 1948 prohibits the use of flowers and leaves that contain many cannabinoids. According to Article 4 of the Act, drugs made from cannabis (flowers and leaves) are prohibited for delivery of doctors and the application of patients.
Cannabis Control Act ; Act No.124 of July 10, 1948
Article 1 The term "Cannabis" as used in this Act means the cannabis plant (Cannabis Sativa L.) and its products; provided, however, that the grown stalk of the cannabis plant and its products (excluding resin.) and the seed of cannabis plant and its products are excluded.
It dose not matter whether the plant contains THC, the law regulates depending on the parts of the plant.A prefectural governor's license "Cannabis Handler" is required for cultivation of Hemp.
Japanese Pharmacopoeia listed: None
However, it was included in Indian Cannabis for 65 years from 1886 to 1951.


Food and drug classification in Japan

Drug:Cannabinoids Drugs, Ex.Sativex
Food:Medical marijuna, CBD oil

Effective component

Cannabis has been found to contain 113 cannabinoids.
Δ9-Tetrahydorocannabinol(Δ9-THC)
CAS Number:1972-08-3
Cannabidiol(CBD)
CAS Number:13956-29-1

property:

Dry flowers have a green and unique sweet smell, but different flavors vary depending on the variety.

Preparation:

Both outdoor and indoor cultivation can be done. In the field, it grows from 1 to 3 meters in 3 to 5 months, and 60 cm after 60 days in the room. The cut flower is dried in a dark place for about 10 days, and then matured for about 6 weeks. It can be harvested from 1 square meter to 4 plants, and about 500 g of flower is obtained, including 5 to 30% cannabinoids. The processing method differs depending on the dosage form, but the plant extract is obtained by alcohol extraction and CO2 extraction.

Dosage form:
There are various methods of intake such as tobacco (smoking), vaporiza (vaporization aspiration), chocolate / cookies (food), chincke / oil, oral spray, capsule, gum, tea, juice, cream, skin patches.

Dose:

Ex.Sativex, 1 time 100μL(THC 2.5mg, CBD 2.7mg); 1 Day 10-30mg The complexity of the mechanism of action is considered to have a large range of individual differences.

Apply:

Pain, depression, hypnosis, appetite promotion, anticancer, intraocular pressure, vomiting, antitumor, anticonvulsant, anxiolytic, and anti-inflammatory Cannabinoid drugs are marketed as pain remedies for multiple sclerosis, and clinical trials for epilepsy, cancer pain, glioma, type 2 diabetes, ulcerative colitis, and schizophrenia are ongoing.

Mechanism of action:

ECS (end cannabinoid system) has body control functions such as appetite, pain, immune adjustment, emotional control, motor function, development and aging, nerve protection, cognition and memory. They support communication activities between cells. Endo-cannabinoids include "anandamide" and "2-AG". There are cannabinoid receptors "CB1" on neurons that bind to them, and cannabinoid receptors "CB2" on immune cells. Receptors are distributed throughout the body. In recent studies, the ECS works weakly "cannabinoid deficiency" with strong external stress or aging. So it has been known to be a different disease.

Adverse event:

In THC, dizziness, thirst, nausea, fatigue, somnolence, euphoria, vomiting, disorientation, lethargy, confusion, confusion, loss of equilibrium, and hallucinations have been reported. In CBD, fatigue and somnolence have been reported.